以下为句子列表：
英文: The progress in tyrosine kinase inhibitor has been reviewed, including the chemical structures and the pharmacophore models.
中文: 本文综述了近年来酪氨酸激酶抑制剂的研究进展，包括抑制剂的结构和与激酶作用的药效团模型。
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英文: This is because once a pharmacophore is known, medicinal chemists can modify it to reduce toxicity while maintaining (or enhancing) potency.
中文: 这是因为一旦知道药效基因，药物化学家就可以修饰它，在保持药效的基础上减少毒性。
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英文: Typically, pharmacophore refers to the combination of atoms and functional groups (together with their three-dimensional positions), that together allow a drug to interact with its target protein in a specific manner and exhibit its pharmacological activi
中文: 一般而言，药效基因是指原子和功能基团的结合，使得药物以特定方式与靶蛋白作用并显示药物活性。
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英文: Development of Pharmacophore Database for GPCR Ligands
中文: GPCR配体药效团数据库的构建
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