以下为句子列表：
英文: And to date, no blockbuster drugs have come out of regulated bioprospecting.
中文: 而且，迄今也没有任何畅销药品来自受管理的生物探勘。
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英文: Big firms have grown risk averse, developing lots of imitations of blockbuster drugs and fewer novel ones.
中文: 大公司已经不愿承担风险，它们开发了许多已被广泛接受药物的效仿品，而创新药品则更少了。
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英文: Many large pharmaceutical companies are struggling to come up with new blockbuster drugs at a time when existing products are coming off patent protection.
中文: 许多大型制药企业现有产品的专利保护即将到期，目前在推出新的主打药物方面有困难。
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