以下为句子列表：
英文: Research Design and Methods:Seeral methods were used to modulate cholesterol leels in intact islets and cultured ?-cells, including a recently deeloped mouse model that exhibits eleated cholesterol but normal free fatty acid leels.
中文: 实验设计和方法：在完整的胰岛及培养的?-细胞中，已有很多方法用于调节胆固醇水平，包括最近兴起的一种大鼠模型，其胆固醇水平增高，但自由脂肪酸正常。
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英文: Empirical research design on earnings management includes aggregate accruals models、specific accrual models and frequency distribution approach.
中文: 盈余管理实证研究方法主要包括总体应计模型、特定应计模型和频率分布方法。
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