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As a result,the pharmacokinetics of matrine in rabbit body coincides with two-compartment open model. For 10-30mg/kg dosage groups,the t_(1/2)β,Vc and CLS are similar basically. A direct proportion increase in AUC as dose is increased.
中文意思:
结果表明,苦参碱在家兔体内药代动力学符合二室开放模型,10~30mg/kg时t_1/2β,V_c,CLS基本相似,AUC与剂量成比例增加,呈线性消除。


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As a result,the pharmacokinetics of matrine in rabbit body coincides with two-compartment open model. For 10-30mg/kg dosage groups,the t_(1/2)β,Vc and CLS are similar basically. A direct proportion increase in AUC as dose is increased. 结果表明,苦参碱在家兔体内药代动力学符合二室开放模型,10~30mg/kg时t_1/2β,V_c,CLS基本相似,AUC与剂量成比例增加,呈线性消除。
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