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Adipokines,the bioactive factors derived mainly from adipocytes, regulate pancreatic β-cell function including insulin secretion,gene expression and apoptosis.In this review,we propose that adipokines influence β-cell function through three interdependent
中文意思:
脂肪因子包括脂肪细胞分泌的多种活性因子,它们通过内分泌方式调节胰岛β细胞的胰岛素分泌、基因表达以及细胞凋亡等多方面的功能.本文提出脂肪因子影响胰岛β细胞功能主要通过三条相互联系的途径而实现.第一是调节β细胞内葡萄糖和脂肪的代谢;第二是影响β细胞离子通道的活性;第三是改变β细胞本身的胰岛素敏感性.脂肪细胞的内分泌功能是一个动态过程,在不同的代谢状态下,各脂肪因子的分泌发生不同变化.从正常代谢状态发展到肥胖以及2型糖尿病的过程中,脂肪因子参与了胰岛β细胞功能障碍的发生与发展.


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