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[Obejectives] A common pathogenetic mechenism of Alzheimer's disease (AD) and Creutzfelt-Jakob Disease (CJD) is the accumulation in the brain of abnormally folded proteins leading to neurodegeneration. |
中文意思: 老年性痴呆(Alzheimer's disease, AD)与Creutzfelt-Jakob病(CJD)同属于ND中的蛋白构象病,其发病是由于蛋白质异常折叠导致构象变化,正常可溶的蛋白质转化成不可溶的蛋白质聚合体,前者为β淀粉样蛋白(β-Amyloid, Aβ)沉积,后者为蛋白酶K抵抗的朊蛋白(Prion Protein, PrP~(SC))沉积。 |
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