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In search of more potent, less toxic and selective potassium channel openers, four novel benzopyran-4-thiourea derivatives(3a~3d) were synthesized and evaluated for vasorelaxant activity against 30 mmol·L-1 KCl inducing contraction of rat aorta in vitro. |
中文意思: 根据苯并吡喃类钾通道开放剂的作用机理和构效关系,合成了4个新的苯并吡喃-4-硫脲类化合物(3a~3d),其结构经1HNMR,IR,MS和元素分析确证。 |
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In search of more potent, less toxic and selective potassium channel openers, four novel benzopyran-4-thiourea derivatives(3a~3d) were synthesized and evaluated for vasorelaxant activity against 30 mmol·L-1 KCl inducing contraction of rat aorta in vitro.
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根据苯并吡喃类钾通道开放剂的作用机理和构效关系,合成了4个新的苯并吡喃-4-硫脲类化合物(3a~3d),其结构经1HNMR,IR,MS和元素分析确证。 |
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